{"topic_id":"evidence_exotic_ferret_clinical","category":"evidence","context":"---\ntopic_id: evidence_exotic_ferret_clinical\ncategory: evidence\ntitle: \"Evidence cluster — Ferret (Mustela putorius furo) clinical cases (peer-reviewed, Europe PMC)\"\nlang: en\nsource: \"Europe PMC (Europe PubMed Central) REST search, first-hand peer-reviewed abstracts, pulled 2026-08-01\"\nsource_file: pdf-raw/evidence/europepmc_ferret_clinical_2026-08-01.txt\ndate_parsed: 2026-08-01\ntokens_estimated: 4259\nverification:\n  method: paraphrase\n  claims: 8\n  passed: 8\n  date: 2026-08-01\nsource_document: \"Peer-reviewed Ferret clinical-case literature (Europe PMC, first-hand abstracts)\"\ncitation:\n  authority: \"Europe PMC\"\n  title: \"Evidence cluster — Ferret (Mustela putorius furo) clinical cases (peer-reviewed, Europe PMC)\"\n  url: \"https://www.ebi.ac.uk/europepmc/\"\n  retrieved: \"2026-08-01\"\n  doc_type: \"first-hand abstracts (Europe PMC REST)\"\n  needs_review: false\ncopyright_note: \"Mixed licensing per COPYRIGHT_POLICY §3: Open Access (CC BY) studies retained verbatim with attribution; non-Open-Access studies paraphrased as derived fact summaries (numbers and proper nouns preserved, sentences rewritten).\"\nlicense: mixed\nauthority_tier: T2\nauthority_tier_basis: \"T2:oa-repo\"\nauthority_tier_date: 2026-08-04\n---\n\n# Evidence: Ferret (Mustela putorius furo) clinical cases\n\nSource: Europe PMC (Europe PubMed Central) REST search — first-hand peer-reviewed abstract records, pulled 2026-08-01.\nQueries covered clinical case reports and case series for Mustela putorius furo.\nThe cluster returns **2** representative clinical cases with abstracts below. Abstract text is verbatim from source; each case is traceable by PMID.\n\n## Studies\n- **PMID 42027880 (2026, Journal of toxicologic pathology)** — An exophytic multinodular chordoma of the cervical spine in a ferret.. Abstract (opening): An 8-year-old male ferret was presented with dyspnea and large, palpable cervical masses. Pathological examination revealed multiple exophytic nodular masses arising from the atlas and axis. Those vertebrae were almost completely replaced by neoplastic tissue. Histologically, the masses were composed of physaliferous cells with foamy cytoplasm embedded within a prominent chondro-osseous matrix. The diagnosis of chordoma was confirmed by immunohistochemistry, as tumor cells were positive for pan-cytokeratin, vimentin, S-100, and neuron-specific enolase. Notably, some chondrocytes and osteocytes adjacent to the tumor cells also expressed these markers, suggesting a neoplastic origin rather than a reactive process. Ki-67 labeling was confined to a subset of cytokeratin-positive cells at the periphery of the nodules, indicating that peripheral proliferation contributes to the exophytic growth pattern. This report describes a case of cervical chordoma with a unique exophytic presentation in a ferret. *[CC BY — Open Access, verbatim with attribution.]*\n  Source: https://pubmed.ncbi.nlm.nih.gov/42027880/\n- **PMID 41482860 (2026, Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc)** — *[Paraphrased derived summary — non-Open-Access source.]* A 5-year-old female ferret presented with anorexia and lethargy and was found to have peripheral lymphadenopathy, splenomegaly, and pneumonia; autopsy revealed 1–4-mm white nodules (pyogranulomas with slender acid-fast bacilli) in lung, spleen, and kidneys, PCR-positive for Mycobacterium celatum — a systemic non-tuberculous mycobacterial infection in a ferret.\n  Source: https://pubmed.ncbi.nlm.nih.gov/41482860/\n\nSource text: `pdf-raw/evidence/europepmc_ferret_clinical_2026-08-01.txt` (Europe PMC first-hand abstracts, pulled 2026-08-01).\n\n## License & attribution\n\nMixed licensing per COPYRIGHT_POLICY §3: Open Access (CC BY / CC BY-NC /\nCC BY-NC-ND) studies are reproduced verbatim with attribution under their specific\nCC license; non-Open-Access studies are paraphrased as derived fact summaries\n(numbers and proper nouns preserved, sentences rewritten). Original records:\n- https://pubmed.ncbi.nlm.nih.gov/42027880/\n- https://pubmed.ncbi.nlm.nih.gov/41482860/\n- https://pubmed.ncbi.nlm.nih.gov/41902252/\n- https://pubmed.ncbi.nlm.nih.gov/42053522/\n- https://pubmed.ncbi.nlm.nih.gov/41600859/\n- https://pubmed.ncbi.nlm.nih.gov/41517886/\n- https://pubmed.ncbi.nlm.nih.gov/41483683/\n- https://pubmed.ncbi.nlm.nih.gov/41586145/\n\n## Cleaning removal log (2026-08-05, codebuddy)\nPMID 42063453 — cutaneous melanoma in a RABBIT, different species\nPMID 41777478 — PGAD in 59-year-old woman, human\nPMID 41612690 — off-topic mis-clustered: oropharyngeal teratoma in neonatal GOAT\nPMID 42081574 — Ebola virus disease in ferrets used as a MODEL organism, not pet subject\nPMID 41902252 — lab-model review (swine influenza animal models), not pet clinical (removed 2026-08-24, kimi)\nPMID 42053522 — lab lung physiology, not pet clinical (removed 2026-08-24, kimi)\nPMID 41600859 — lab-model review (influenza encephalitis models), not pet clinical (removed 2026-08-24, kimi)\nPMID 41517886 — human influenza surveillance (Central African Republic), not pet clinical (removed 2026-08-24, kimi)\nPMID 41483683 — virology platform review (henipaviruses), not pet clinical (removed 2026-08-24, kimi)\nPMID 41586145 — mis-clustered — dog case (pit bull liver torsion), not ferret (removed 2026-08-24, kimi)\n","sources":["Europe PMC — Evidence cluster — Ferret (Mustela putorius furo) clinical cases (peer-reviewed, Europe PMC) (retrieved 2026-08-01)"],"source":{"authority":"Europe PMC","title":"Evidence cluster — Ferret (Mustela putorius furo) clinical cases (peer-reviewed, Europe PMC)","url":"https://pubmed.ncbi.nlm.nih.gov/42027880/","retrieved":"2026-08-01","ref":"PMID 42027880","doc_type":"official PDF","source_document":"Peer-reviewed Ferret clinical-case literature (Europe PMC, first-hand abstracts)","verification_file":"pdf-raw/evidence/europepmc_ferret_clinical_2026-08-01.txt"},"source_document":"Peer-reviewed Ferret clinical-case literature (Europe PMC, first-hand abstracts)","source_file":"pdf-raw/evidence/europepmc_ferret_clinical_2026-08-01.txt","trust":{"authority_tier":"T2","fidelity":"paraphrase","license":"mixed","display_grade":"B"},"tokens_estimated":600,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}