{"topic_id":"evidence_exotic_rabbit_clinical","category":"evidence","context":"---\ntopic_id: evidence_exotic_rabbit_clinical\ncategory: evidence\ntitle: \"Evidence cluster — Rabbit (Oryctolagus cuniculus) clinical cases (peer-reviewed, Europe PMC)\"\nlang: en\nsource: \"Europe PMC (Europe PubMed Central) REST search, first-hand peer-reviewed abstracts, pulled 2026-08-01\"\nsource_file: pdf-raw/evidence/europepmc_rabbit_clinical_2026-08-01.txt\ndate_parsed: 2026-08-01\ntokens_estimated: 4258\nverification:\n method: paraphrase\n claims: 2\n passed: 2\n date: 2026-08-01\nsource_document: \"Peer-reviewed Rabbit clinical-case literature (Europe PMC, first-hand abstracts)\"\ncitation:\n authority: \"Europe PMC\"\n title: \"Evidence cluster — Rabbit (Oryctolagus cuniculus) clinical cases (peer-reviewed, Europe PMC)\"\n url: \"https://www.ebi.ac.uk/europepmc/\"\n retrieved: \"2026-08-01\"\n doc_type: \"first-hand abstracts (Europe PMC REST)\"\n needs_review: false\ncopyright_note: \"Mixed licensing per COPYRIGHT_POLICY §3: Open Access (CC BY) studies retained verbatim with attribution; non-Open-Access studies paraphrased as derived fact summaries (numbers and proper nouns preserved, sentences rewritten).\"\nlicense: mixed\nauthority_tier: T2\nauthority_tier_basis: \"T2:oa-repo\"\nauthority_tier_date: 2026-08-04\n---\n\n# Evidence: Rabbit (Oryctolagus cuniculus) clinical cases\n\nSource: Europe PMC (Europe PubMed Central) REST search — first-hand peer-reviewed abstract records, pulled 2026-08-01.\nQueries covered clinical case reports and case series for Oryctolagus cuniculus.\nThe cluster returns **2** representative clinical cases with abstracts below. Abstract text is verbatim from source; each case is traceable by PMID.\n\n## Studies\n- **PMID 42464972 (2026, Veterinary ophthalmology)** — *[Paraphrased derived summary — non-Open-Access source.]* A 2-year-old male giant rabbit with chronic recurrent corneal erosions due to eyelid/third-eyelid conformational abnormality was treated by wedge excision of the upper eyelid and shortening of the third-eyelid cartilage; erosions resolved completely with no recurrence over 1 year. (Source excerpt truncated at abstract opening.)\n Source: https://pubmed.ncbi.nlm.nih.gov/42464972/\n- **PMID 42063453 (2026, Case reports in veterinary medicine)** — Cutaneous Melanoma in a Rabbit With Multiple Metastatic Lesions: A Case Report.. Abstract (opening): Background
Neoplasia is increasingly common in senior pet rabbits, with cutaneous melanoma being a rare but aggressive type. Its characteristics in rabbits are not fully understood.Case description
A 5-year-old rabbit initially presented with a cutaneous mass at the ear base. Despite surgical excision, it recurred rapidly with multiple facial/chest masses and pulmonary metastases, leading to euthanasia. Pathological evaluation confirmed malignant melanoma, revealing features such as high mitotic activity and lymphovascular invasion; immunohistochemistry provided the definitive diagnosis.Conclusion and clinical relevance
This case highlights the highly aggressive and metastatic nature of cutaneous melanoma in rabbits, often resulting in a poor prognosis. Clinicians should be aware of melanoma's aggressive potential in rabbits. Surgical intervention alone may prove inadequate, and current treatment options in rabbits are limited. In this case, surgical intervention was not effective, likely because micrometastasis was already present. Treatment options remain limited, and euthanasia is often required in metastatic cases. *[CC BY — Open Access, verbatim with attribution.]*\n Source: https://pubmed.ncbi.nlm.nih.gov/42063453/\n\nSource text: `pdf-raw/evidence/europepmc_rabbit_clinical_2026-08-01.txt` (Europe PMC first-hand abstracts, pulled 2026-08-01).\n\n## License & attribution\n\nMixed licensing per COPYRIGHT_POLICY §3: Open Access (CC BY / CC BY-NC /\nCC BY-NC-ND) studies are reproduced verbatim with attribution under their specific\nCC license; non-Open-Access studies are paraphrased as derived fact summaries\n(numbers and proper nouns preserved, sentences rewritten). Original records:\n- https://pubmed.ncbi.nlm.nih.gov/42464972/\n- https://pubmed.ncbi.nlm.nih.gov/42063453/\n\n## Cleaning removal log (2026-08-05, codebuddy)\nPMID 42254076 — human ROS1 lung adenocarcinoma IHC case — off-topic (human)\nPMID 42255890 — human delayed hypersensitivity to insulin — off-topic (human)\nPMID 41889221 — canine (Finnish Lapphund) cutaneous sarcoidosis — other-species (dog), mis-clustered (pre-labeled)\nPMID 42188604 — human Fea's viper envenoming case — off-topic (human)\nPMID 42225084 — human KSHV/HIV Kaposi-associated disorders — off-topic (human)\nPMID 42319213 — canine haemangiosarcoma in a dog — other-species (dog)\nPMID 42079309 — human adolescent dissociative identity disorder + ECT — off-topic (human)\nPMID 42029971 — human maxillary carcinoma cuniculatum (HIV) — off-topic (human)\nPMID 42095012 — feline adrenal pheochromocytoma — other-species (cat)\nPMID 42045647 — human pulmonary epithelial-myoepithelial carcinoma — off-topic (human)\n","sources":["Europe PMC — Evidence cluster — Rabbit (Oryctolagus cuniculus) clinical cases (peer-reviewed, Europe PMC) (retrieved 2026-08-01)"],"source":{"authority":"Europe PMC","title":"Evidence cluster — Rabbit (Oryctolagus cuniculus) clinical cases (peer-reviewed, Europe PMC)","url":"https://pubmed.ncbi.nlm.nih.gov/42464972/","retrieved":"2026-08-01","ref":"PMID 42464972","doc_type":"official PDF","source_document":"Peer-reviewed Rabbit clinical-case literature (Europe PMC, first-hand abstracts)","verification_file":"pdf-raw/evidence/europepmc_rabbit_clinical_2026-08-01.txt"},"source_document":"Peer-reviewed Rabbit clinical-case literature (Europe PMC, first-hand abstracts)","source_file":"pdf-raw/evidence/europepmc_rabbit_clinical_2026-08-01.txt","trust":{"authority_tier":"T2","fidelity":"paraphrase","license":"mixed","display_grade":"B"},"tokens_estimated":600,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}