{"topic_id":"evidence_exotic_rabbit_toxicology","category":"evidence","context":"---\ntopic_id: evidence_exotic_rabbit_toxicology\ncategory: evidence\ntitle: \"Evidence cluster — Rabbit (Oryctolagus cuniculus) toxicology (peer-reviewed, Europe PMC)\"\nlang: en\nsource: \"Europe PMC (Europe PubMed Central) REST search, first-hand peer-reviewed abstracts, pulled 2026-08-01\"\nsource_file: pdf-raw/evidence/europepmc_rabbit_toxicology_2026-08-01.txt\ndate_parsed: 2026-08-01\ntokens_estimated: 5936\nverification:\n  method: paraphrase\n  claims: 3\n  passed: 3\n  date: 2026-08-01\nsource_document: \"Peer-reviewed Rabbit toxicology literature (Europe PMC, first-hand abstracts)\"\ncitation:\n  authority: \"Europe PMC\"\n  title: \"Evidence cluster — Rabbit (Oryctolagus cuniculus) toxicology (peer-reviewed, Europe PMC)\"\n  url: \"https://www.ebi.ac.uk/europepmc/\"\n  retrieved: \"2026-08-01\"\n  doc_type: \"first-hand abstracts (Europe PMC REST)\"\n  needs_review: false\ncopyright_note: \"Mixed licensing per COPYRIGHT_POLICY §3: Open Access (CC BY) studies retained verbatim with attribution; non-Open-Access studies paraphrased as derived fact summaries (numbers and proper nouns preserved, sentences rewritten).\"\nlicense: mixed\nauthority_tier: T2\nauthority_tier_basis: \"T2:oa-repo\"\nauthority_tier_date: 2026-08-04\n---\n\n# Evidence: Rabbit (Oryctolagus cuniculus) toxicology\n\nSource: Europe PMC (Europe PubMed Central) REST search — first-hand peer-reviewed abstract records, pulled 2026-08-01.\nQueries covered toxicology, poisoning, intoxication, heavy metals, mycotoxins and (for relevant taxa) envenomation for Oryctolagus cuniculus.\nThe cluster returns **1** representative studies with abstracts below. Abstract text is verbatim from source; each study is traceable by PMID.\n\n## Studies\n- **PMID 41594534 (2026, Animals : an open access journal from MDPI)** — Encephalitozoonosis in Pet Rabbits: Epidemiology, Pathogenesis, Immunology and Consensus on Clinical Management.. Abstract (opening): Members of the microsporidial genus <i>Encephalitozoon</i> have the capacity to infect both mammals and birds, and <i>E. cuniculi</i> is most commonly found in rabbits. With a seroprevalence ranging up to 85%, <i>E. cuniculi</i> can be a problem in pet rabbits as well as in food production and laboratory animal science. While most infections are likely subclinical, there are three main clinical presentations: neurological, renal, and ocular. Typical clinical signs including vestibular disease and phacoclastic uveitis may develop with initial or relapsing infection, while renal infection is usually progressive and associated with non-specific clinical signs. High-sensitivity/specificity ante mortem diagnostic options are lacking, and serological testing most often provides adjunct rather than definitive information such that physical examination and other diagnostics are used more so for ruling out other differentials and comorbidities, rather than confirming infection. In the veterinary community, treatment regimens are variable given the lack of thorough studies and a consensus. The aim of this document is to present the available literature to give a concise review of this organism and its infection of rabbits as well as to propose guidelines and protocols for diagnostics and treatment regimens. In addition, the current challenges and recommendations for further studies are discussed. *[CC BY — Open Access, verbatim with attribution.]*\n  Source: https://pubmed.ncbi.nlm.nih.gov/41594534/\n\nSource text: `pdf-raw/evidence/europepmc_rabbit_toxicology_2026-08-01.txt` (Europe PMC first-hand abstracts, pulled 2026-08-01).\n\n## License & attribution\n\nMixed licensing per COPYRIGHT_POLICY §3: Open Access (CC BY / CC BY-NC /\nCC BY-NC-ND) studies are reproduced verbatim with attribution under their specific\nCC license; non-Open-Access studies are paraphrased as derived fact summaries\n(numbers and proper nouns preserved, sentences rewritten). Original records:\n- https://pubmed.ncbi.nlm.nih.gov/42346410/\n- https://pubmed.ncbi.nlm.nih.gov/42149351/\n- https://pubmed.ncbi.nlm.nih.gov/41594534/\n\n## Cleaning removal log (2026-08-05, codebuddy)\nPMID 42341106 — human ALDH variants / ethanol neurotoxicity in mice — other-species (mice/human), not rabbit\nPMID 41938863 — Glaesserella parasuis CDT cytotoxicity in pig PK15 cells — other-species (pig cell line)\nPMID 41789561 — in-silico deep-learning acute dermal toxicity model — no animal, not rabbit\nPMID 42123454 — synthetic cannabinoid AKB-48 neurotoxicity in mice — other-species (mice)\nPMID 42305710 — BaiYangJie on cisplatin nephrotoxicity in mice — other-species (mice)\nPMID 42487466 — rabbit coronary-artery smooth-muscle Kv currents (vascular pharmacology) — off-topic, mis-clustered (pre-labeled)\nPMID 42185944 — recognising intoxication in human healthcare — off-topic (human)\nPMID 41756586 — rabbit used as PK model for oclacitinib hydrogel; conclusion is dogs/cats — lab-model, other-species conclusion\nPMID 42193971 — neonatal HIE calretinin/parvalbumin in piglets/human — other-species (piglets/human)\nPMID 42346410 — lab-model toxicology (Cr(VI) drinking-water exposure), not a pet-rabbit hazard (removed 2026-08-24, kimi)\nPMID 42149351 — lab model (Langendorff-perfused rabbit hearts, anesthetics), not pet toxicology (removed 2026-08-24, kimi)\n","sources":["Europe PMC — Evidence cluster — Rabbit (Oryctolagus cuniculus) toxicology (peer-reviewed, Europe PMC) (retrieved 2026-08-01)"],"source":{"authority":"Europe PMC","title":"Evidence cluster — Rabbit (Oryctolagus cuniculus) toxicology (peer-reviewed, Europe PMC)","url":"https://pubmed.ncbi.nlm.nih.gov/41594534/","retrieved":"2026-08-01","ref":"PMID 41594534","doc_type":"official PDF","source_document":"Peer-reviewed Rabbit toxicology literature (Europe PMC, first-hand abstracts)","verification_file":"pdf-raw/evidence/europepmc_rabbit_toxicology_2026-08-01.txt"},"source_document":"Peer-reviewed Rabbit toxicology literature (Europe PMC, first-hand abstracts)","source_file":"pdf-raw/evidence/europepmc_rabbit_toxicology_2026-08-01.txt","trust":{"authority_tier":"T2","fidelity":"paraphrase","license":"mixed","display_grade":"B"},"tokens_estimated":600,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}