{"topic_id":"exotic_tox_guinea_pig_penicillin_syndromes","category":"exotic-pet-toxicology","context":"---\ntopic_id: exotic_tox_guinea_pig_penicillin_syndromes\ncategory: exotic-pet-toxicology\ntitle: \"Penicillin toxicity syndromes in guinea pigs — toxic, hemorrhagic, chronic (Green 1974, PMID 4446629)\"\nlang: en\nsource: \"First-hand veterinary toxicology reference, saved to source_file; every claim is a C1 byte-substring of it. Deepened 2026-08-01.\"\nsource_file: pdf-raw/exotic-toxicology/pubmed_4446629_penicillin_guineapig_hamster.txt\ndate_parsed: 2026-08-01\ntokens_estimated: 223\nverification:\n  method: substring_match\n  claims: 5\n  passed: 5\n  date: 2026-08-01\nrecovered: false\npath: exotic-pet-toxicology/exotic_tox_guinea_pig_penicillin_syndromes/01_exotic_tox_guinea_pig_penicillin_syndromes.md\nsource_document: \"Green RH (1974) The association of viral activation with penicillin toxicity in guinea pigs and hamsters. Yale Journal of Biology and Medicine 47(3):166-81. PMID 4446629 / PMC2595098.\"\ncitation:\n  authority: \"Green RH (1974) The association of viral activation with penicillin toxicity in guinea pigs and hamsters. Yale Journal of Biology and Medicine 47(3):166-81. PMID 4446629 / PMC2595098.\"\n  title: \"The association of viral activation with penicillin toxicity in guinea pigs and hamsters\"\n  url: \"https://pmc.ncbi.nlm.nih.gov/articles/PMC2595098/\"\n  retrieved: \"2026-08-01\"\n  ref: \"\"\n  doc_type: \"open-access journal article\"\n  needs_review: false\nlicense: cc_by\ncopyright_note: 'Reclassified from mislabeled \"Merck Veterinary Manual\" (source_file is PubMed/PMC article PMID 4446629 / PMC2595098, open access). Verbatim reproduction with attribution permitted per COPYRIGHT_POLICY §2.'\nauthority_tier: T2\nauthority_tier_basis: \"T2:oa-journal\"\nauthority_tier_date: 2026-08-04\n---\n\n# Penicillin toxicity syndromes in guinea pigs — toxic, hemorrhagic, chronic (Green 1974, PMID 4446629)\n\nThe text below is reproduced verbatim from the first-hand source.\n\n## Claims (verified C1 substrings of source_file)\n\n- `The association of viral activation with penicillin toxicity in guinea pigs and \nhamsters.`\n- `This finding has been construed as being activation \nof a latent virus by this antibiotic, but the relationship, if any, of the \nphenomenon of viral activation to the syndromes produced by penicillin and its \nfrequent lethal toxicity is unknown.`\n- `Of some 60 guinea pigs which received injections of \npenicillin three developed tumors and four others were found to have gallstones.`\n- `A virus similar or identical to the guinea pig virus also has been isolated from \nhamsters dying of penicillin-induced disease.`\n- `It is hypothesized that the \nabsorption of endotoxin, resulting from the well known change in intestinal \nflora caused by penicillin, produces a state of immunodeficiency which regularly \ngives rise to activation of a latent virus, and perhaps, rarely, to the \ndevelopment of malignant neoplasms.`\n\n---\n\n**Source:** `pdf-raw/exotic-toxicology/pubmed_4446629_penicillin_guineapig_hamster.txt` · https://pmc.ncbi.nlm.nih.gov/articles/PMC2595098/\n","sources":["exotic-pet-toxicology — The association of viral activation with penicillin toxicity in guinea pigs and hamsters (retrieved 2026-08-01)"],"source":{"authority":"exotic-pet-toxicology","title":"The association of viral activation with penicillin toxicity in guinea pigs and hamsters","url":"https://pubmed.ncbi.nlm.nih.gov/4446629/","retrieved":"2026-08-01","ref":"PMID 4446629","doc_type":"official PDF","source_document":"Green RH (1974) The association of viral activation with penicillin toxicity in guinea pigs and hamsters. Yale Journal of Biology and Medicine 47(3):166-81. PMID 4446629 / PMC2595098.","verification_file":"pdf-raw/exotic-toxicology/pubmed_4446629_penicillin_guineapig_hamster.txt"},"source_document":"Green RH (1974) The association of viral activation with penicillin toxicity in guinea pigs and hamsters. Yale Journal of Biology and Medicine 47(3):166-81. PMID 4446629 / PMC2595098.","source_file":"pdf-raw/exotic-toxicology/pubmed_4446629_penicillin_guineapig_hamster.txt","trust":{"authority_tier":"T2","fidelity":"verbatim","license":"cc_by","display_grade":"A"},"tokens_estimated":364,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}