Boxer — Ventricular arrhythmias and sudden death (hereditary; OMIA-verified breed predisposition)

--- license: permission_granted topic_id: companion_breed_health_boxer_omia1785_dog category: companion-breed-health title: "Boxer — Ventricular arrhythmias and sudden death (hereditary; OMIA-verified breed predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump." source_file: pdf-raw/breed-health/boxer_omia1785_1785.txt date_parsed: 2026-08-02 tokens_estimated: 91 verification: method: substring_match claims: 4 passed: 4 date: 2026-08-02 recovered: false path: companion-breed-health/companion_breed_health_boxer_omia1785_dog/01_companion_breed_health_boxer_omia1785_dog.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Boxer — Ventricular arrhythmias and sudden death (hereditary; OMIA-verified breed predisposition)" url: "https://omia.org/OMIA001040/9615/" retrieved: "2026-08-02" ref: "OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (breed-specific disorder entries)" needs_review: false

Boxer — Ventricular arrhythmias and sudden death (hereditary; OMIA-verified breed predisposition)

Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.

Claims

• Breed: Boxer (Dog)
• Disorder:
• Defect: yes
• Prevalence: Meurs et al. (2019): the variant was significantly associated with the arrhythmia in the Rhodesian Ridgeback family (p = 0.001) and was identified as homozygous in the affected offspring and heterozygous in both of the parents.

Associated gene(s)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• Gene: Entrez Gene ID 388245149 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene
• OMIA molecular-genetics note: Meurs et al. (2019): "A single missense G/A variant in the QIL1 [also called MICOS13, C20H19ORF70] gene was associated with the cardiac arrhythmia (p < 0.0001). The variant was predicted to change the amino acid from conserved Glycine to Serine and to be deleterious."

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• 1994. Inherited ventricular arrhythmias and sudden death in German Shepherd dogs. Journal of the American College of Cardiology — PubMed:PMID8006271 — OMIA Phene_Article / Article
• 1996. Phenylephrine-induced ventricular arrhythmias in dogs with inherited sudden death. Journal of Cardiovascular Electrophysiology — PubMed:PMID8867296 — OMIA Phene_Article / Article
• 1996. Triggered activity as a mechanism for inherited ventricular arrhythmias in German Shepherd dogs. Journal of the American College of Cardiology — PubMed:PMID8626969 — OMIA Phene_Article / Article
• 1997. Heterogeneous sympathetic innervation in german shepherd dogs with inherited ventricular arrhythmia and sudden cardiac death. Circulation — PubMed:PMID9286967 — OMIA Phene_Article / Article
• 1999. Abnormal cardiac repolarization and impulse initiation in German shepherd dogs with inherited ventricular arrhythmias and sudden death. Cardiovascular Research — PubMed:PMID10434997 — OMIA Phene_Article / Article
• 1999. Familial ventricular arrhythmias in boxers. Journal of Veterinary Internal Medicine — PubMed:PMID10499727 — OMIA Phene_Article / Article
• 2000. Electropharmacological characterization of cardiac repolarization in German shepherd dogs with an inherited syndrome of sudden death: Abnormal response to potassium channel blockers. Journal of the American College of Cardiology — PubMed:PMID10987623 — OMIA Phene_Article / Article
• 2000. beta(1) and beta(2)-adrenergic receptor subtype effects in German shepherd dogs with inherited lethal ventricular arrhythmias. Cardiovascular Research — PubMed:PMID11054468 — OMIA Phene_Article / Article
• 2004. Mechanisms of alpha-adrenergic potentiation of ventricular arrhythmias in dogs with inherited arrhythmic sudden death. Cardiovasc Res — PubMed:PMID14985068 | DOI:10.1016/j.cardiores.2003.12.025 — OMIA Phene_Article / Article
• 2003. Heterogeneous ventricular repolarization provides a substrate for arrhythmias in a German shepherd model of spontaneous arrhythmic death. Circulation — PubMed:PMID12939224 | DOI:10.1161/01.CIR.0000086461.86642.22 — OMIA Phene_Article / Article
• 2005. Regional dispersion of L-type calcium current in ventricular myocytes of German shepherd dogs with lethal cardiac arrhythmias. Heart Rhythm — PubMed:PMID15851292 | DOI:10.1016/j.hrthm.2004.10.041 — OMIA Phene_Article / Article
• 2011. Implantable cardioverter-defibrillator in a German shepherd dog with ventricular arrhythmias. J Vet Cardiol — PubMed:PMID21849269 | DOI:10.1016/j.jvc.2011.04.006 — OMIA Phene_Article / Article
• (16 additional references in OMIA)

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• OMIM:618329 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
• OMIM:616658 (type: gene) — OMIA Group_OMIM (via OMIA_ID)

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."