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Collie — Optic nerve hypoplasia, bilateral (hereditary; OMIA-verified breed predisposition)

companion_breed_health_collie_omia1366_dog

Other Compilations derived_from_dataset companion-breed-health

--- license: permission_granted topic_id: companion_breed_health_collie_omia1366_dog category: companion-breed-health title: "Collie — Optic nerve hypoplasia, bilateral (hereditary; OMIA-verified breed predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump." source_file: pdf-raw/breed-health/collie_omia1366_1366.txt date_parsed: 2026-08-02 tokens_estimated: 102 verification: method: substring_match claims: 4 passed: 4 date: 2026-08-02 recovered: false path: companion-breed-health/companion_breed_health_collie_omia1366_dog/01_companion_breed_health_collie_omia1366_dog.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Collie — Optic nerve hypoplasia, bilateral (hereditary; OMIA-verified breed predisposition)" url: "https://omia.org/OMIA000743/9615/" retrieved: "2026-08-02" ref: "OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (breed-specific disorder entries)" needs_review: false

Collie — Optic nerve hypoplasia, bilateral (hereditary; OMIA-verified breed predisposition)

Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.

Claims

  • Breed: Collie (Dog)
  • Disorder:
  • Summary: Genetics Committee of the American College of Veterinary Opthalmologists (2021): a congenital anomaly, which results in a small optic disk diameter and vision loss.Contrast with micropapilla, which may have a similar ophthalmoscopic appearance but without loss of vision.
  • Defect: yes

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.

  • 1952. Congenital optic nerve hypoplasia in Collie dogs. Cornell Veterinarian — PubMed:PMID14905886 — OMIA Phene_Article / Article
  • 1971. Case report. Bilateral optic nerve hypoplasia in two dogs.. Can Vet J — PubMed:PMID5104935 — OMIA Phene_Article / Article
  • 1976. Bilateral optic nerve hypoplasia in a pup.. J Am Vet Med Assoc — PubMed:PMID1245453 — OMIA Phene_Article / Article
  • 1981. Optic nerve hypoplasia in three Miniature Poodles.. J Am Vet Med Assoc — PubMed:PMID7204223 — OMIA Phene_Article / Article
  • 1998. What is your diagnosis? Congenital optic nerve hypoplasia in a dog.. J Small Anim Pract — PubMed:PMID9494926 — OMIA Phene_Article / Article
  • 2008. Distinctive histopathologic features of canine optic nerve hypoplasia and aplasia: a retrospective review of 13 cases.. Vet Ophthalmol — PubMed:PMID18190348 | DOI:10.1111/j.1463-5224.2007.00596.x — OMIA Phene_Article / Article
  • 2020. Optic nerve hypoplasia in miniature poodle dogs: A preliminary genetic and candidate gene association study.. Vet Ophthalmol — PubMed:PMID31342635 | DOI:10.1111/vop.12691 — OMIA Phene_Article / Article
  • 2021. The Blue Book: Ocular disorders presumed to be inherited in purebred dogs. 13th Edition. https://ofa.org/wp-content/uploads/2022/10/ACVO-Blue-Book-2021.pdf — OMIA Phene_Article / Article

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. Links this animal disorder to its human OMIM entry for comparative/translational context.

  • OMIM:165550 (type: trait) — OMIA Group_OMIM (via OMIA_ID)

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.

  • 1952. Congenital optic nerve hypoplasia in Collie dogs. Cornell Veterinarian — PubMed:PMID14905886 — OMIA Phene_Article / Article
  • 1971. Case report. Bilateral optic nerve hypoplasia in two dogs. Can Vet J — PubMed:PMID5104935 — OMIA Phene_Article / Article
  • 1976. Bilateral optic nerve hypoplasia in a pup. J Am Vet Med Assoc — PubMed:PMID1245453 — OMIA Phene_Article / Article
  • 1981. Optic nerve hypoplasia in three Miniature Poodles. J Am Vet Med Assoc — PubMed:PMID7204223 — OMIA Phene_Article / Article
  • 1998. What is your diagnosis? Congenital optic nerve hypoplasia in a dog. J Small Anim Pract — PubMed:PMID9494926 — OMIA Phene_Article / Article
  • 2008. Distinctive histopathologic features of canine optic nerve hypoplasia and aplasia: a retrospective review of 13 cases. Vet Ophthalmol — PubMed:PMID18190348 | DOI:10.1111/j.1463-5224.2007.00596.x — OMIA Phene_Article / Article
  • 2020. Optic nerve hypoplasia in miniature poodle dogs: A preliminary genetic and candidate gene association study. Vet Ophthalmol — PubMed:PMID31342635 | DOI:10.1111/vop.12691 — OMIA Phene_Article / Article
  • 2021. The Blue Book: Ocular disorders presumed to be inherited in purebred dogs. 13th Edition. https://ofa.org/wp-content/uploads/2022/10/ACVO-Blue-Book-2021.pdf — OMIA Phene_Article / Article

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. Links this animal disorder to its human OMIM entry for comparative/translational context.

  • OMIM:165550 (type: trait) — OMIA Group_OMIM (via OMIA_ID)

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 1952. Congenital optic nerve hypoplasia in Collie dogs. Cornell Veterinarian — PubMed:PMID14905886 — OMIA Phene_Article / Article
  • 1971. Case report. Bilateral optic nerve hypoplasia in two dogs. Can Vet J — PubMed:PMID5104935 — OMIA Phene_Article / Article
  • 1976. Bilateral optic nerve hypoplasia in a pup. J Am Vet Med Assoc — PubMed:PMID1245453 — OMIA Phene_Article / Article
  • 1981. Optic nerve hypoplasia in three Miniature Poodles. J Am Vet Med Assoc — PubMed:PMID7204223 — OMIA Phene_Article / Article
  • 1998. What is your diagnosis? Congenital optic nerve hypoplasia in a dog. J Small Anim Pract — PubMed:PMID9494926 — OMIA Phene_Article / Article
  • 2008. Distinctive histopathologic features of canine optic nerve hypoplasia and aplasia: a retrospective review of 13 cases. Vet Ophthalmol — PubMed:PMID18190348 | DOI:10.1111/j.1463-5224.2007.00596.x — OMIA Phene_Article / Article
  • 2020. Optic nerve hypoplasia in miniature poodle dogs: A preliminary genetic and candidate gene association study. Vet Ophthalmol — PubMed:PMID31342635 | DOI:10.1111/vop.12691 — OMIA Phene_Article / Article
  • 2021. The Blue Book: Ocular disorders presumed to be inherited in purebred dogs. 13th Edition. https://ofa.org/wp-content/uploads/2022/10/ACVO-Blue-Book-2021.pdf — OMIA Phene_Article / Article

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • OMIM:165550 (type: trait) — OMIA Group_OMIM (via OMIA_ID)

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 1952. Congenital optic nerve hypoplasia in Collie dogs. Cornell Veterinarian — PubMed:PMID14905886 — OMIA Phene_Article / Article
  • 1971. Case report. Bilateral optic nerve hypoplasia in two dogs. Can Vet J — PubMed:PMID5104935 — OMIA Phene_Article / Article
  • 1976. Bilateral optic nerve hypoplasia in a pup. J Am Vet Med Assoc — PubMed:PMID1245453 — OMIA Phene_Article / Article
  • 1981. Optic nerve hypoplasia in three Miniature Poodles. J Am Vet Med Assoc — PubMed:PMID7204223 — OMIA Phene_Article / Article
  • 1998. What is your diagnosis? Congenital optic nerve hypoplasia in a dog. J Small Anim Pract — PubMed:PMID9494926 — OMIA Phene_Article / Article
  • 2008. Distinctive histopathologic features of canine optic nerve hypoplasia and aplasia: a retrospective review of 13 cases. Vet Ophthalmol — PubMed:PMID18190348 | DOI:10.1111/j.1463-5224.2007.00596.x — OMIA Phene_Article / Article
  • 2020. Optic nerve hypoplasia in miniature poodle dogs: A preliminary genetic and candidate gene association study. Vet Ophthalmol — PubMed:PMID31342635 | DOI:10.1111/vop.12691 — OMIA Phene_Article / Article
  • 2021. The Blue Book: Ocular disorders presumed to be inherited in purebred dogs. 13th Edition. https://ofa.org/wp-content/uploads/2022/10/ACVO-Blue-Book-2021.pdf — OMIA Phene_Article / Article

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • OMIM:165550 (type: trait) — OMIA Group_OMIM (via OMIA_ID)

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 1952. Congenital optic nerve hypoplasia in Collie dogs. Cornell Veterinarian — PubMed:PMID14905886 — OMIA Phene_Article / Article
  • 1971. Case report. Bilateral optic nerve hypoplasia in two dogs. Can Vet J — PubMed:PMID5104935 — OMIA Phene_Article / Article
  • 1976. Bilateral optic nerve hypoplasia in a pup. J Am Vet Med Assoc — PubMed:PMID1245453 — OMIA Phene_Article / Article
  • 1981. Optic nerve hypoplasia in three Miniature Poodles. J Am Vet Med Assoc — PubMed:PMID7204223 — OMIA Phene_Article / Article
  • 1998. What is your diagnosis? Congenital optic nerve hypoplasia in a dog. J Small Anim Pract — PubMed:PMID9494926 — OMIA Phene_Article / Article
  • 2008. Distinctive histopathologic features of canine optic nerve hypoplasia and aplasia: a retrospective review of 13 cases. Vet Ophthalmol — PubMed:PMID18190348 | DOI:10.1111/j.1463-5224.2007.00596.x — OMIA Phene_Article / Article
  • 2020. Optic nerve hypoplasia in miniature poodle dogs: A preliminary genetic and candidate gene association study. Vet Ophthalmol — PubMed:PMID31342635 | DOI:10.1111/vop.12691 — OMIA Phene_Article / Article
  • 2021. The Blue Book: Ocular disorders presumed to be inherited in purebred dogs. 13th Edition. https://ofa.org/wp-content/uploads/2022/10/ACVO-Blue-Book-2021.pdf — OMIA Phene_Article / Article

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • OMIM:165550 (type: trait) — OMIA Group_OMIM (via OMIA_ID)

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."

Machine access

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