Curly Horse (Horse) — Curly coat, KRT25-related (hereditary; OMIA-verified breed predisposition)

Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.

Claims

Breed: Curly Horse (Horse)
Disorder:
Mode of inheritance: Autosomal dominant
Summary: Morgenthaler et al. (2017): First described by Crow and Sioux Native American tribes as early as 1801 during winter horse counting [Thomas et al., 1989], Curly horses present a variety of coat curl phenotypes associated with diverse degrees of curliness which can range from “minimal” scattered curled hair up to extremely dense “micro curled” permanent coat as observed in certain Missouri Fox Trotter lines.nbsp;
Defect: yes

Associated gene(s)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

Gene: Entrez Gene ID 388944862 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene
OMIA molecular-genetics note: Morgenthaler et al. (2017): "whole-genome sequences were obtained for one heterozygous curly stallion and its straight-haired son. Among the four non-synonymous candidate variants identified and validated in the curly region, only variant g.21891160G>A in the <em>KRT25</em> gene (KRT25:p.R89H) [omia.variant:856] was in perfect agreement with haplotype status in the whole pedigree. Genetic assoc…

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

1940. Inheritance of curliness in the horse. C.R. (Doklady) Academy of Science U.R.S.S., N.S. — OMIA Phene_Article / Article
1990. Dominant Curly Coat in Horses. Genetics Selection Evolution — OMIA Phene_Article / Article
2016. Rare phenotypes in domestic animals: unique resources for multiple applications. Anim Genet — PubMed:PMID26662214 | DOI:10.1111/age.12393 — OMIA Phene_Article / Article
2017. A missense variant in the coil1A domain of the keratin 25 gene is associated with the dominant curly hair coat trait (Crd) in horse. Genet Sel Evol — PubMed:PMID29141579 | DOI:10.1186/s12711-017-0359-5 — OMIA Phene_Article / Article
1989. Myth and mystery: the curly horse in America. New York: C.S. Fund Inc. — OMIA Phene_Article / Article
1943. Curly coat of horses. Journal of Heredity — OMIA Phene_Article / Article
2018. An epistatic effect of KRT25 on SP6 is involved in curly coat in horses. Sci Rep — PubMed:PMID29686323 | DOI:10.1038/s41598-018-24865-3 — OMIA Phene_Article / Article
2024. Horse allergy: Curly Horses can mediate immune tolerance. Pneumologie — PubMed:PMID37827498 | DOI:10.1055/a-2101-9533 — OMIA Phene_Article / Article
2024. Predicted genetic burden and frequency of phenotype-associated variants in the horse. Sci Rep — PubMed:PMID38600096 | DOI:10.1038/s41598-024-57872-8 — OMIA Phene_Article / Article

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

OMIM:616760 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
OMIM:616646 (type: gene) — OMIA Group_OMIM (via OMIA_ID)

Curly Horse (Horse) — Curly coat, KRT25-related (hereditary; OMIA-verified breed predisposition)