Rabbit (Oryctolagus cuniculus) โ Cystic fibrosis (hereditary; OMIA-verified species predisposition)
Source: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Species: Rabbit (Oryctolagus cuniculus)Disorder: Cystic fibrosisSummary: Yang et al. (2020) "report the production of CFTR-ฮF508 rabbits by CRISPR/Cas9-mediated gene editing." This study involves genetically modified organisms (GMO).
Associated gene(s)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- Gene: Entrez Gene ID 398298869 (no symbol in OMIA GeneSynonym) โ OMIA Phene_Gene
Evidence (references)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- 2024. Sotagliflozin attenuates liver associated disorders in cystic fibrosis rabbits. JCI Insight โ PubMed:PMID38358827 | DOI:10.1172/jci.insight.165826 โ OMIA Phene_Article / Article
- 2021. Phenotypes of CF rabbits generated by CRISPR/Cas9-mediated disruption of the CFTR gene. JCI Insight โ PubMed:PMID33232302 | DOI:10.1172/jci.insight.139813 โ OMIA Phene_Article / Article
- 2020. Production of CFTR-ฮF508 rabbits. Front Genet โ PubMed:PMID33552140 | DOI:10.3389/fgene.2020.627666 โ OMIA Phene_Article / Article
- 2023. Cystic fibrosis rabbits develop spontaneous hepatobiliary lesions and CF-associated liver disease (CFLD)-like phenotypes. PNAS Nexus โ PubMed:PMID36712930 | DOI:10.1093/pnasnexus/pgac306 โ OMIA Phene_Article / Article
- 2021. Intestinal dysbiosis in young cystic fibrosis rabbits. J Pers Med โ PubMed:PMID33669429 | DOI:10.3390/jpm11020132 โ OMIA Phene_Article / Article
- 2024. Endocrine pathology in young rabbits with cystic fibrosis. eGastroenterology โ PubMed:PMID39605883 | DOI:10.1136/egastro-2024-100102 โ OMIA Phene_Article / Article
- 2026. Male reproductive phenotype in cystic fibrosis: comparison of existing animal models. Lab Anim (NY) โ PubMed:PMID42380629 | DOI:10.1038/s41684-026-01763-0 โ OMIA Phene_Article / Article
Comparative medicine (human OMIM)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- OMIM:219700 (type: trait) โ OMIA Group_OMIM (via OMIA_ID)
- OMIM:602421 (type: gene) โ OMIA Group_OMIM (via OMIA_ID)