Cat (Felis catus) — Deafness, LHFPL5-related (hereditary; OMIA-verified species predisposition)

Source: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.

Claims

Species: Cat (Felis catus)
Disorder: Deafness, LHFPL5-related
Clin feat: Perret et al (2025): "A 30‐month‐old cat was presented with a chronic history of deafness, vestibular signs, intermittent aggressive behavior, and vocalizations. The owners reported that the cat had never shown any normal response to noise or calling. ...  Neurological examination identified loud vocalizations while pacing into the room, which were subjectively judged to be related to hearing impairment rather than pain. A bilateral head swaying movement was also observed together with a low head and body posture close to the ground ... . An ophthalmological examination was unremarkable."

Associated gene(s)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

Gene: Entrez Gene ID 398299077 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene
OMIA molecular-genetics note: Perret et al (2025): "Whole‐genome sequencing of the affected cat [with deafness and vestibular signs] and comparison with 106 control genomes identified a private homozygous splice site variant in the <em>LHFPL5</em> gene, XM_003986102.4:c.413‐2A>G [omia.variant:1862]. ... The LHFPL5 protein is essential for hearing and balance, as it anchors the tip link of inner ear hair cells to the me…

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

2025. LHFPL5 splice site variant in a cat with deafness and vestibular dysfunction. Anim Genet — PubMed:PMID41400044 | DOI:10.1002/age.70062 — OMIA Phene_Article / Article

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

OMIM:609427 (type: gene) — OMIA Group_OMIM (via OMIA_ID)
OMIM:610265 (type: trait) — OMIA Group_OMIM (via OMIA_ID)

Cat (Felis catus) — Deafness, LHFPL5-related (hereditary; OMIA-verified species predisposition)