Cat (Felis catus) — Deficient acetaminophen glucuronidation (hereditary; OMIA-verified species predisposition)

Source: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.

Claims

Species: Cat (Felis catus)
Disorder: Deficient acetaminophen glucuronidation
Gen test: Since all cats lack this gene, there is no need for any genetic testing

Associated gene(s)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

Gene: Entrez Gene ID 83148755 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene
OMIA molecular-genetics note: By cloning and sequencing a very likely candidate gene (based on the observation that "The domestic cat has a significantly lower capacity to glucuronidate planar phenolic xenobiotics compared with most other mammalian species"), Court and Greenblatt (2000) showed that all cats are homozygous for a mutated form of the UGT1A6 gene that encodes UDP-glucuronosyltransferase 1A6, and hence completely l…

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

2011. Evolution of a major drug metabolizing enzyme defect in the domestic cat and other felidae: phylogenetic timing and the role of hypercarnivory. PLoS One — PubMed:PMID21464924 | DOI:10.1371/journal.pone.0018046 — OMIA Phene_Article / Article
2000. Molecular genetic basis for deficient acetaminophen glucuronidation by cats: UGT1A6 is a pseudogene, and evidence for reduced diversity of expressed hepatic UGT1A isoforms. Pharmacogenetics — PubMed:PMID10862526 — OMIA Phene_Article / Article
1958. Do cats form glucuronides?. Biochemical journal — OMIA Phene_Article / Article
1972. The fate of (14C)phenol in various species. Xenobiotica — PubMed:PMID4211177 — OMIA Phene_Article / Article
1997. Molecular basis for deficient acetaminophen glucuronidation in cats. An interspecies comparison of enzyme kinetics in liver microsomes. Biochem Pharmacol — PubMed:PMID9174118 — OMIA Phene_Article / Article
1972. Species differences in biotransformation and excretion of salicylate. Am J Vet Res — PubMed:PMID5022404 — OMIA Phene_Article / Article
1984. The toxicity and biotransformation of single doses of acetaminophen in dogs and cats. Toxicol Appl Pharmacol — PubMed:PMID6729821 — OMIA Phene_Article / Article
1997. Biochemical basis for deficient paracetamol glucuronidation in cats: an interspecies comparison of enzyme constraint in liver microsomes. J Pharm Pharmacol — PubMed:PMID9232546 — OMIA Phene_Article / Article
2014. Comparing the glucuronidation capacity of the feline liver with substrate-specific glucuronidation in dogs. J Vet Pharmacol Ther — PubMed:PMID23888985 | DOI:10.1111/jvp.12067 — OMIA Phene_Article / Article

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

OMIM:606431 (type: gene) — OMIA Group_OMIM (via OMIA_ID)

Cat (Felis catus) — Deficient acetaminophen glucuronidation (hereditary; OMIA-verified species predisposition)