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Horse (Equus caballus) — Multiple acyl-CoA dehydrogenase deficiency (hereditary; OMIA-verified species predisposition)

companion_species_health_multiple_acyl_coa_dehydrogenase_deficiency_horse

Other Compilations derived_from_dataset companion-species-health

Horse (Equus caballus) — Multiple acyl-CoA dehydrogenase deficiency (hereditary; OMIA-verified species predisposition)

Source: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.

Claims

  • Species: Horse (Equus caballus)
  • Disorder: Multiple acyl-CoA dehydrogenase deficiency
  • Mode of inheritance: Because this disorder is due to the ingestion of a toxin, it is not inherited. It is included in OMIA because it is a phenocopy of an inherited disorder that occurs in humans (see MIM entry above) and in cats (see OMIA 001457-9685).
  • Summary: This equine disorder is an interesting example of a phenocopy, i.e. the phenotype of an inherited disorder that has a non-genetic cause. In this case, the non-genetic cause is ingestion of a toxin from microbes on plant leaves. In humans, there are inherited forms of this disorder due to mutations in three different genes (ETFA, ETFB, ETFDH) whose peptides are involved in electron transfer in the mitochondrial respiratory chain: see the MIM entry above. For another example of a phenocopy, see OMIA 000625-9913.

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 1959. Contribution a l'etude de la pathogenie et du traitement de la myoglobinurie paroxystique due cheval. Revue de Medecine Veterinaire — OMIA Phene_Article / Article
  • 2008. Acquired multiple Acyl-CoA dehydrogenase deficiency in 10 horses with atypical myopathy. Neuromuscular Disorders — PubMed:PMID18406615 | DOI:10.1016/j.nmd.2008.02.007 — OMIA Phene_Article / Article
  • 2013. [Multiple Acyl-CoA Dehydrogenase Deficiency (MADD) in the horse]. Tijdschr Diergeneeskd — PubMed:PMID23847852 — OMIA Phene_Article / Article
  • 2012. Equine multiple acyl-CoA dehydrogenase deficiency (MADD) associated with seasonal pasture myopathy in the midwestern United States. J Vet Intern Med — PubMed:PMID22708588 | DOI:10.1111/j.1939-1676.2012.00957.x — OMIA Phene_Article / Article
  • 2007. Equine biochemical multiple acyl-CoA dehydrogenase deficiency (MADD) as a cause of rhabdomyolysis. Mol Genet Metab — PubMed:PMID17540595 | DOI:10.1016/j.ymgme.2007.04.010 — OMIA Phene_Article / Article
  • 2010. Equine acquired multiple acyl-CoA dehydrogenase deficiency (MADD) in 14 horses associated with ingestion of Maple leaves (Acer pseudoplatanus) covered with European tar spot (Rhytisma acerinum). Mol Genet Metab — PubMed:PMID20655779 | DOI:10.1016/j.ymgme.2010.06.019 — OMIA Phene_Article / Article
  • 2011. Decreased oxidative phosphorylation and PGAM deficiency in horses suffering from atypical myopathy associated with acquired MADD. Mol Genet Metab — PubMed:PMID21843962 | DOI:10.1016/j.ymgme.2011.07.022 — OMIA Phene_Article / Article

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • OMIM:231680 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:231675 (type: gene) — OMIA Group_OMIM (via OMIA_ID)

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 1959. Contribution a l'etude de la pathogenie et du traitement de la myoglobinurie paroxystique due cheval. Revue de Medecine Veterinaire — OMIA Phene_Article / Article
  • 2008. Acquired multiple Acyl-CoA dehydrogenase deficiency in 10 horses with atypical myopathy. Neuromuscular Disorders — PubMed:PMID18406615 | DOI:10.1016/j.nmd.2008.02.007 — OMIA Phene_Article / Article
  • 2013. [Multiple Acyl-CoA Dehydrogenase Deficiency (MADD) in the horse]. Tijdschr Diergeneeskd — PubMed:PMID23847852 — OMIA Phene_Article / Article
  • 2012. Equine multiple acyl-CoA dehydrogenase deficiency (MADD) associated with seasonal pasture myopathy in the midwestern United States. J Vet Intern Med — PubMed:PMID22708588 | DOI:10.1111/j.1939-1676.2012.00957.x — OMIA Phene_Article / Article
  • 2007. Equine biochemical multiple acyl-CoA dehydrogenase deficiency (MADD) as a cause of rhabdomyolysis. Mol Genet Metab — PubMed:PMID17540595 | DOI:10.1016/j.ymgme.2007.04.010 — OMIA Phene_Article / Article
  • 2010. Equine acquired multiple acyl-CoA dehydrogenase deficiency (MADD) in 14 horses associated with ingestion of Maple leaves (Acer pseudoplatanus) covered with European tar spot (Rhytisma acerinum). Mol Genet Metab — PubMed:PMID20655779 | DOI:10.1016/j.ymgme.2010.06.019 — OMIA Phene_Article / Article
  • 2011. Decreased oxidative phosphorylation and PGAM deficiency in horses suffering from atypical myopathy associated with acquired MADD. Mol Genet Metab — PubMed:PMID21843962 | DOI:10.1016/j.ymgme.2011.07.022 — OMIA Phene_Article / Article

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • OMIM:231680 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:231675 (type: gene) — OMIA Group_OMIM (via OMIA_ID)

Machine access

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