Rabbit (Oryctolagus cuniculus) — Precocious puberty, MKRN3-related (hereditary; OMIA-verified species predisposition)

Rabbit (Oryctolagus cuniculus) — Precocious puberty, MKRN3-related (hereditary; OMIA-verified species predisposition)

Source: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.

Claims

• Species: Rabbit (Oryctolagus cuniculus)
• Disorder: Precocious puberty, MKRN3-related
• Summary: Chen et al. (2025) developped a MKRN3-modified rabbit using CRISPR gene editing technology (GMO) as a model for central precocious puberty (CPP) in children.

Associated gene(s)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• Gene: Entrez Gene ID 398298979 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• 2025. A novel model of central precocious puberty disease: Paternal MKRN3 gene-modified rabbit. Animal Model Exp Med — PubMed:PMID39854156 | DOI:10.1002/ame2.12544 — OMIA Phene_Article / Article

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• OMIM:615346 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
• OMIM:603856 (type: gene) — OMIA Group_OMIM (via OMIA_ID)