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Dog (Canis lupus familiaris) — X-linked progressive retinal atrophy (hereditary; OMIA-verified species predisposition)

companion_species_health_x_linked_progressive_retinal_atrophy_dog

Other Compilations derived_from_dataset companion-species-health

Dog (Canis lupus familiaris) — X-linked progressive retinal atrophy (hereditary; OMIA-verified species predisposition)

Source: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.

Claims

  • Species: Dog (Canis lupus familiaris)
  • Disorder: X-linked progressive retinal atrophy
  • Clin feat: Bionda et al. (2026) report related male English Cocker Spaniel dogs with a progressive vision deficit. Retinal pathology was recorded around 3-4 years of age with a possible earlier onset of visual impairment.  

Associated gene(s)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • Gene: Entrez Gene ID 398299092 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene
  • OMIA molecular-genetics note: Bionda et al. (2026) identified a 1-bp deletion in exon 36 of the <em>CACNA1F</em> gene (NC_049260.1:g.42,516,353del; XM_038587436.1:c.4,481del, XP_038443364.1:p.Phe1482LeufsTer8; omia.variant:1881) as likely causal variant for a novel form of &nbsp;X-linked progressive retinal atrophy in related English Cocker Spaniel dogs.

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 2026. Deletion in CACNA1F gene causes X-linked progressive retinal atrophy in English Cocker Spaniel dogs. BMC Vet Res — PubMed:PMID41882631 | DOI:10.1186/s12917-026-05421-y — OMIA Phene_Article / Article

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • OMIM:300110 (type: gene) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:300476 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:300071 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:300600 (type: trait) — OMIA Group_OMIM (via OMIA_ID)

Machine access

AI agents: this compilation is also available as GET /api/v1/llm_context?topic=companion_species_health_x_linked_progressive_retinal_atrophy_dog (max 500 tokens, whitelisted).

Raw JSON ↗ llm.txt OpenAPI