American Pit Bull Terrier — Calvarial hyperostotic syndrome (hereditary; OMIA-verified breed predisposition)
Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Breed: American Pit Bull Terrier (Dog)Disorder:Clin feat: Letko et a. (2020): persistent and sharp pain when opening mouth, painful swelling of the jaw, fever, and in some cases also severe pain of ulna and radius bones.Defect: yes
Associated gene(s)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- OMIA entry symbol: CHS (no structured Phene_Gene link)
- OMIA molecular-genetics note: Letko et al. (2020) whole-genome sequenced an affected American Staffordshire Terrier but were not able to identify a likely causal variant.
Evidence (references)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- 2012. Calvarial hyperostosis presenting as unilateral exophthalmos in a female English Springer Spaniel. Vet Ophthalmol — PubMed:PMID22192474 | DOI:10.1111/j.1463-5224.2011.00969.x — OMIA Phene_Article / Article
- 2011. Idiopathic canine juvenile cranial hyperostosis in a Pit Bull Terrier. N Z Vet J — PubMed:PMID21660851 | DOI:10.1080/00480169.2011.579556 — OMIA Phene_Article / Article
- 2020. Whole genome sequencing indicates heterogeneity of hyperostotic disorders in dogs. Genes (Basel) — PubMed:PMID32033218 | DOI:10.3390/genes11020163 — OMIA Phene_Article / Article
- 2000. Idiopathic hyperostosis of the calvaria in five young bullmastiffs. J Am Anim Hosp Assoc — PubMed:PMID10997521 | DOI:10.5326/15473317-36-5-439 — OMIA Phene_Article / Article
- 2006. Calvarial hyperostosis syndrome in two bullmastiffs. Vet Radiol Ultrasound — PubMed:PMID16429988 | DOI:10.1111/j.1740-8261.2005.00108.x — OMIA Phene_Article / Article
- 2015. Calvarial hyperostosis syndrome in a young Weimaraner dog. Vlaams Diergeneeskundig Tijdschrift — OMIA Phene_Article / Article
- 2025. Suspected calvarial hyperostosis syndrome causing different ophthalmological signs in two young Labrador Retrievers-Case report. Vet Ophthalmol — PubMed:PMID39988334 | DOI:10.1111/vop.70007 — OMIA Phene_Article / Article
Comparative medicine (human OMIM)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- OMIM:302030 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."