Basenji — spontaneous Fanconi syndrome, idiopathic Fanconi syndrome (hereditary; OMIA-verified breed predisposition)

Basenji — spontaneous Fanconi syndrome, idiopathic Fanconi syndrome (hereditary; OMIA-verified breed predisposition)

Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.

Claims

• Breed: Basenji (Dog)
• Disorder: spontaneous Fanconi syndrome, idiopathic Fanconi syndrome
• Mode of inheritance: Autosomal recessive
• Summary: Information listed here was previously listed under OMIA:000366-9615 : Fanconi syndrome in Canis lupus familiaris
• `Clin feat: Fanconi syndrome is a rare condition in dogs which results in abnormal renal function. More specifically, it causes reduced function of the proximal convoluted tubules (Yearley et al., 2004), resulting in reduced reabsorption of water, nutrients and electrolytes from the tubular fluid and their eventual loss in urine. The clinical consequences of this disease for the animal include polyuria and polydipsia, dehydration, weight loss and muscle weakness (Yearley et al., 2004). Most cases progress to renal failure within a few years of the onset of initial clinical signs Bovée et al. (1978, PMID:684432). Tijdschr Diergeneeskd — PubMed:PMID16130757 — OMIA Phene_Article / Article
• 2004. Survival time, lifespan, and quality of life in dogs with idiopathic Fanconi syndrome. J Am Vet Med Assoc — PubMed:PMID15328712 | DOI:10.2460/javma.2004.225.377 — OMIA Phene_Article / Article
• 1989. Cystinuria in dogs: comparison of the cystinuric component of the Fanconi syndrome in Basenji dogs to isolated cystinuria. Metabolism — PubMed:PMID2909832 | DOI:10.1016/0026-0495(89)90173-x — OMIA Phene_Article / Article
• 1982. Renal tubular defects of spontaneous Fanconi syndrome in dogs. Prog Clin Biol Res — PubMed:PMID7122624 — OMIA Phene_Article / Article
• 1981. Proline and glucose transport by renal membranes from dogs with spontaneous idiopathic Fanconi syndrome. Proc Natl Acad Sci U S A — PubMed:PMID6950417 | DOI:10.1073/pnas.78.12.7769 — OMIA Phene_Article / Article
• 1979. Characterization of renal defects in dogs with a syndrome similar to the Fanconi syndrome in man. J Am Vet Med Assoc — PubMed:PMID438041 — OMIA Phene_Article / Article
• 1978. Spontaneous Fanconi syndrome in the dog. Metabolism — PubMed:PMID619225 | DOI:10.1016/0026-0495(78)90122-1 — OMIA Phene_Article / Article
• (4 additional references in OMIA)

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• OMIM:613534 (type: gene) — OMIA Group_OMIM (via OMIA_ID)
• OMIM:614817 (type: trait) — OMIA Group_OMIM (via OMIA_ID)

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."