Beagle — Factor VII deficiency (hereditary; OMIA-verified breed predisposition)
Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Breed: Beagle (Dog)Disorder:Mode of inheritance: Autosomal recessive- `Clin feat: Ramirez et al. (2019) report that the disease results in mild to moderate bleeding propensity, but in most cases it is identified by chance when regular coagulation screenings result in extended prothrombin times (PT). Kaae et al. (2008) report that clinical presentation includes subcutaneous hematoma formation, blood loss anemia, and a history of abnormal bleeding. [Japanese]. Experimental Animals — PubMed:PMID3436375 — OMIA Phene_Article / Article
- 1970. The assay of human factor VII by means of modified factor VII deficient dog plasma. British Journal of Maematology — PubMed:PMID5416591 — OMIA Phene_Article / Article
- 1967. Factor VII deficiency in Beagle dog plasma and its use in the assay of human factor VII. Nature — PubMed:PMID6075264 — OMIA Phene_Article / Article
- 2003. Sensitivity of different prothrombin time assays to factor VII deficiency in canine plasma. Veterinary Journal — OMIA Phene_Article / Article
- (28 additional references in OMIA)
Comparative medicine (human OMIM)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- OMIM:227500 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
- OMIM:613878 (type: gene) — OMIA Group_OMIM (via OMIA_ID)
verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."