Domestic Medium Hair — Multidrug resistance 1, ABCB1-related (hereditary; OMIA-verified breed predisposition)
Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Breed: Domestic Medium Hair (Cat)Disorder:Mode of inheritance: A recessive mode of inheritance has been considered. In other species an incomplete dominant mode of inheritance is discussed.- `Clin feat: Multidrug resistance 1 results in higher risk of adverse drug reactions to P-glycoprotein substrate drugs such as ivermectin and macrocyclic lactones due to impaired P-glycoprotein synthesis. These drugs are commonly found in flea and tick preventatives for cats and dogs (Mealey et al., 2023). Clinical effects can be neurological such as CNS depression, ataxia, seizure activity, tremors, hypersalivation, vomiting, mydriasis, dyspnoea, and in severe cases, coma, blindness and death. It can also manifest in bone marrow suppression in the form of neutropenia and thrombocytopenia. Gatstrointestinal toxicity has also been reported (Mealey et al., 2021).