Domestic Shorthair — Congenital adrenal hypoplasia (CAH) (hereditary; OMIA-verified breed predisposition)
Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Breed: Domestic Shorthair (Cat)Disorder: Congenital adrenal hypoplasia (CAH)Mode of inheritance: Autosomal recessive- `Clin feat: Key clinical features reflect the deficiency of the enzyme (11β-hydroxylase) and consequential impaired biosynthesis of cortisol and changes to androgen levels (Owens et al., 2012; Stachowiak, 2022), including presence of indeterminant or secondary sex characteristics post desexing, including gynecomastia (enlarged breast tissue) concurrent with fully formed penis with barbs (Knighton, 2004; Owens et al., 2012); intermale aggression (Owens et al., 2012); unexplained hypertension and excess salt and water retention (Owens et al., 2012); polyuria and polydipsia (Knighton, 2004; Owens et al., 2012); foul-smelling and minimally concentrated urine (Owens et al., 2012); small body frame, thickened skin and greasy haircoat (Owens et al., 2012); decreased baseline and stimulated serum cortisol and aldosterone concentrations (Owens et al., 2012); increased baseline and stimulated progesterone and androstenedione concentrations (Owens et al., 2012) and increased serum urea nitrogen concentration, hypernatremia, hyperglobulinemia (Owens et al., 2012).