Domestic Shorthair — Polydactyly (hereditary; OMIA-verified breed predisposition)
Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Breed: Domestic Shorthair (Cat)Disorder:Mode of inheritance: Autosomal dominant with incomplete penetrance- `Clin feat: Polydactyly in cats is a congenital deformity, clinically characterized by the presence of more than 18 digits in total at birth, with the additional digit(s) on either their front and/or hind limb(s). A variety of combinations of different numbers of extra toes per paw have been observed, while the distribution of extra digits exhibits a non-continuous statistical pattern (Lange et al., 2013). Polydactyl cats not only have an unusual number and shape of digits, but they may also exhibit unharmful altered conformation of carpus and tarsus (Hamelin et al., 2016). Kleintierpraxis — OMIA Phene_Article / Article
- 1966. The independent assortment of dominant white and polydactyly in the cat. J Hered — PubMed:PMID5917255 — OMIA Phene_Article / Article
- 2008. Point mutations in a distant sonic hedgehog cis-regulator generate a variable regulatory output responsible for preaxial polydactyly. Hum Mol Genet — PubMed:PMID18156157 | DOI:10.1093/hmg/ddm370 — OMIA Phene_Article / Article
- 1976. Mutant allele frequencies among domestic cats in some eastern areas of Canada: regional homogeneity of factors in Canadian Atlantic Provinces and the French colony of Saint Pierre. J Hered — PubMed:PMID1021595 — OMIA Phene_Article / Article
- 2007. Hemingway's cats: to have or have not?. National Geographic — OMIA Phene_Article / Article
- 1947. Heredity of polydactyly in the cat. J Hered — PubMed:PMID20242531 — OMIA Phene_Article / Article
- 1947. Morphology of the feet in polydactyl cats. Am J Anat — PubMed:PMID20286212 — OMIA Phene_Article / Article
- 1968. Polydactylism in cats. Vet Med Small Anim Clin — PubMed:PMID5188319 — OMIA Phene_Article / Article
- 1902. Prepotency in polydactylous cats. Science — PubMed:PMID17833849 | DOI:10.1126/science.16.405.554 — OMIA Phene_Article / Article
- (8 additional references in OMIA)
Comparative medicine (human OMIM)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- OMIM:174500 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
- OMIM:605522 (type: gene) — OMIA Group_OMIM (via OMIA_ID)
- OMIM:188740 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."