German Shepherd Dog — Leukocyte adhesion deficiency, type III (hereditary; OMIA-verified breed predisposition)
Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Breed: German Shepherd Dog (Dog)Disorder:Mode of inheritance: Autosomal recessive- `Clin feat: Key clinical signs include pyrexia, bleeding diathesis, and dental disease (Hugo Heading, 2014; Boudreaux et al.,2010). Other signs may include joint effusions (Hugo Heading, 2014), lameness, and infections, such as pododermatitis, deep pyoderma, and cellulitis (Boudreaux et al., 2010). Bleeding diathesis has been noted to occur following injury or surgery (Boudreaux et al., 2010; Hugo and Heading, 2014). Affected dogs have persistent leukocytosis and neutrophilia (Hugo Heading, 2014; Boudreaux et al., 2010). Assays of haemostasis may yield variable results, including prolonged buccal mucosal bleeding times, normal coagulation screening assays and vWF antigen concentration, and delayed platelet aggregation and clot retraction (Hugo Heading, 2014; Boudreaux et al., 2010).