Greyhound — Drug metabolism, altered (hereditary; OMIA-verified breed predisposition)
Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Breed: Greyhound (Dog)Disorder:Summary: Martinez et al. (2024): Greyhounds metabolize cytochrome P450 (CYP) 2B11 substrates more slowly than other dog breeds.Defect: unknown
Associated gene(s)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- Gene: Entrez Gene ID 398298941 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene
- Gene: Entrez Gene ID 398298942 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene
- Gene: Entrez Gene ID 398299028 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene
- OMIA molecular-genetics note: Martinez et al. (2020) investigatd suspected CYP2B11 deficiency in Greyhounds: "Greyhound livers metabolized CYP2B11 substrates slower, possessed lower CYP2B11 protein abundance, but had similar or higher mRNA expression than other breeds. Gene resequencing identified three CYP2B11 haplotypes, H1 (reference), H2, and H3 that were differentiated by mutations in the gene 3'-untranslated region (3'-U…
Evidence (references)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- 2024. Pharmacogenomics of poor drug metabolism in greyhounds: Canine P450 oxidoreductase genetic variation, breed heterogeneity, and functional characterization. PLoS One — PubMed:PMID38300925 | DOI:10.1371/journal.pone.0297191 — OMIA Phene_Article / Article
- 2020. Pharmacogenomics of poor drug metabolism in Greyhounds: Cytochrome P450 (CYP) 2B11 genetic variation, breed distribution, and functional characterization. Sci Rep — PubMed:PMID31919457 | DOI:10.1038/s41598-019-56660-z — OMIA Phene_Article / Article
- 2019. Absolute quantitation of drug-metabolizing cytochrome P450 enzymes and accessory proteins in dog liver microsomes using label-free standard-free analysis reveals interbreed variability. Drug Metab Dispos — PubMed:PMID31427433 | DOI:10.1124/dmd.119.088070 — OMIA Phene_Article / Article
- 2024. A variety of cytochrome P450 enzymes and flavin-containing monooxygenases in dogs and pigs commonly used as preclinical animal models. Biochem Pharmacol — PubMed:PMID38490520 | DOI:10.1016/j.bcp.2024.116124 — OMIA Phene_Article / Article
- 2024. Relevance of pharmacogenetics and pharmacogenomics in veterinary clinical practice: A review. Anim Genet — PubMed:PMID37990577 | DOI:10.1111/age.13376 — OMIA Phene_Article / Article
- 2025. Adverse drug-drug interaction between phenobarbital and Fluconazole in two dogs. J Vet Intern Med — PubMed:PMID40682369 | DOI:10.1111/jvim.70190 — OMIA Phene_Article / Article
verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."