Old English Sheepdog — classical haemophilia/hemophilia (hereditary; OMIA-verified breed predisposition)

companion_breed_health_old_english_sheepdog_classical_haemophilia_hemophilia_dog

Old English Sheepdog — classical haemophilia/hemophilia (hereditary; OMIA-verified breed predisposition)

Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.

Claims

Breed: Old English Sheepdog (Dog)
Disorder: classical haemophilia/hemophilia
Mode of inheritance: X-linked recessive
Summary: The historical section of this entry is based on information in the review by Lozier and Nichols (2013). Some missing references were also gleaned from this review. FN is grateful to the authors for their very useful review.
`Clin feat: Dogs with haemophilia A present with spontaneous bleeding, including bleeding in soft tissue, joints (causing lameness) and body cavities. Excessive bleeding is reported after tooth extraction or after deciduous teeth are lost and after surgery (Mischke et al., 1996; Nichols et al., 2010). Coagulation analysis will show a markedly prolonged activated partial thromboplastin time (APTT) with a low factor VIII activity (Gavazza et al., 2014; Nishitani and Kitoh, 2021). Severity of clinical presentation varies between breeds.

Sources

Old English Sheepdog — classical haemophilia/hemophilia (hereditary; OMIA-verified breed predisposition)

Source document: OMIA — Online Mendelian Inheritance in Animals (University of Sydney)

OMIA — Online Mendelian Inheritance in Animals (University of Sydney)

OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70

retrieved 2026-08-02

Verification file: pdf-raw/breed-health/old_english_sheepdog_classical_haemophilia_hemophilia_56.txt

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