Sphynx — Sphynx hairless; Atrichia (hereditary; OMIA-verified breed predisposition)
Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Breed: Sphynx (Cat)Disorder: Sphynx hairless; AtrichiaMode of inheritance: Autosomal recessive- `Clin feat: Sphynx cats have abnormal hair shafts, with deficits in both Henle’s and Huxley’s layer of the inner root sheath and the dermal papillae, accompanied by small, curved hair follicles (Genovese et al., 2014; Mota-Rojas et al., 2021). The resulting follicular dysplasia has been attributed to the mutated form of keratin 71, ultimately giving rise to the hairless appearance of Sphynx cats (Gandolfi et al., 2010; Genovese et al., 2014). This absence of hair impedes thermoregulation by reducing insulation, making Sphynx cats sensitive to temperature extremes (Mota-Rojas et al., 2021). Sphynx cats are also prone to greasiness of the skin and higher carriage of cutaneous Malassezia (yeast) than DSH cats, attributed to their almost-hairlessness (Åhman and Bergström, 2009).