Rabbit (Oryctolagus cuniculus) — Diabetes mellitus (hereditary; OMIA-verified species predisposition)
Source: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Species: Rabbit (Oryctolagus cuniculus)Disorder: Diabetes mellitusSummary: Song et al. (2019) developed a "rabbit with a non-frameshift mutation of GCK gene (GCK-NFS) by cytoplasm microinjection of Cas9 mRNA and gRNA. These GCK-NFS rabbits showed typical features of MODY-2 including hyperglycemia and glucose intolerance with similar survival rate and weight compared to wild-type (WT) rabbits." This is a genetically-modified organism (GMO).
Associated gene(s)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- Gene: Entrez Gene ID 389108310 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene
Evidence (references)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- 1998. Diabetes mellitus in rabbits, guinea pigs and chinchillas [German]. Kleintierpraxis — OMIA Phene_Article / Article
- 2019. Genetic deletion of a short fragment of glucokinase in rabbit by CRISPR/Cas9 leading to hyperglycemia and other typical features seen in MODY-2. Cell Mol Life Sci — PubMed:PMID31720743 | DOI:10.1007/s00018-019-03354-4 — OMIA Phene_Article / Article
- 2023. Contribution of animal models to diabetes research: Its history, significance, and translation to humans. J Diabetes Investig — PubMed:PMID37401013 | DOI:10.1111/jdi.14034 — OMIA Phene_Article / Article
Comparative medicine (human OMIM)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- OMIM:125850 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
- OMIM:125851 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
- OMIM:125852 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
- OMIM:125853 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
- OMIM:176730 (type: gene) — OMIA Group_OMIM (via OMIA_ID)
- OMIM:222100 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
- OMIM:222300 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
- OMIM:520000 (type: trait) — OMIA Group_OMIM (via OMIA_ID)