Cat (Felis catus) — feline alimentary T cell lymphoma; epitheliotropic intestinal T-Cell lymphomas (hereditary; OMIA-verified species predisposition)
Source: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Species: Cat (Felis catus)Disorder: feline alimentary T cell lymphoma; epitheliotropic intestinal T-Cell lymphomasSummary: Kieslinger et al. (2021): "Analysis of 42 samples of feline T cell alimentary lymphoma reveals broad activation of STAT3 and STAT5B. Screening for known activating mutations in STAT3 or STAT5B identifies the presence of the STAT5B^N642H [omia.variant:1425] driver mutation in feline enteropathy-associated T cell lymphoma in 7 out of 42 (16.67%) samples in total. Regarding lymphoma subtypes, the majority of mutations with 5 out of 17 (29.41%) cases were found in feline enteropathy-associated lymphoma type II (EATL II)." IT IS IMPORTANT TO NOTE THAT THIS IS UNDERSTOOD TO BE A SOMATIC MUTATION, WHICH MEANS THAT THE VARIANT IS NOT INHERITED AND WILL NOT BE PASSED ON TO OFFSPRING.- `Clin feat: A cat with EATL may present with a history of reduced or increased appetite, vomiting, lethargy, diarrhoea, constipation, and weight loss. Weight loss related to muscle wasting is the most common sign (Marsilio et al., 2023). The clinical findings in these cats may include abdominal pain or discomfort, muscle loss, diffusely thickened intestinal walls, enlarged mesenteric lymph nodes or masses within the abdomen. Clinical signs may be minimal or absent (Marsilio et al., 2023).