Hamster — Severe combined immunodeficiency disease, X-linked (hereditary; OMIA-verified species predisposition)
Source: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Species: Mesocricetus auratus / Phodopus spp. (hamster)Disorder:Summary: This disorder in hamsters has been produced by targeted disruption of the IL2RG gene (natural mutations in which cause X-linked SCID in dogs and humans). Thus, the reports in this entry concern a genetically-modified organism (GMO)Defect: yes
Associated gene(s)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- Gene: Entrez Gene ID 392706634 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene
Evidence (references)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- 2020. Generation and characterization of an IL2RG knockout Syrian hamster model for XSCID and HAdV-C6 infection in immunocompromised patients. Dis Model Mech — PubMed:PMID32651192 | DOI:10.1242/dmm.044602 — OMIA Phene_Article / Article
Comparative medicine (human OMIM)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- OMIM:300400 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
- OMIM:308380 (type: gene) — OMIA Group_OMIM (via OMIA_ID)
- OMIM:312863 (type: trait) — OMIA Group_OMIM (via OMIA_ID)