Evidence: Guinea pig (Cavia porcellus) clinical cases
Source: Europe PMC (Europe PubMed Central) REST search — first-hand peer-reviewed abstract records, pulled 2026-08-01. Queries covered clinical case reports and case series for Cavia porcellus. The cluster returns 2 representative clinical cases with abstracts below. Abstract text is verbatim from source; each case is traceable by PMID.
Studies
- PMID 42076742 (2026, Veterinary sciences) — Multidrug-Resistant <i>Escherichia coli</i> Causing Respiratory and Systemic Infection in a Guinea Pig (<i>Cavia porcellus</i>) in Romania: A Case Report.. Abstract (opening): <h4>Background/objectives</h4>Multidrug-resistant (MDR) <i>Escherichia coli</i> has increasingly been recognized as a pathogen capable of causing severe systemic infections in various animal species. However, reports describing respiratory and septicemic infections caused by MDR <i>E. coli</i> in guinea pigs remain scarce. The objective of this report was to describe the clinical, pathological, and microbiological findings associated with a fatal infection in a domestic guinea pig.<h4>Case study</h4>A 10-month-old female guinea pig (<i>Cavia porcellus</i>), kept as a companion animal in a household environment, presented with acute respiratory distress, lethargy, and anorexia, progressing rapidly to death within approximately 36 h of onset. Post-mortem examination revealed severe pulmonary congestion, diffuse inflammatory lesions in the trachea, and generalized vascular congestion in multiple organs. Bacteriological cultures obtained from lung and bone marrow samples yielded pure growth of <i>Escherichia coli</i>. Identification was confirmed using MALDI-TOF mass spectrometry. Antimicrobial susceptibility testing demonstrated resistance to several antibiotic classes, including β-lactams, fluoroquinolones, tetracyclines, sulfonamides, and phenicols, while susceptibility was retained only to aminoglycosides. Molecular analysis revealed the presence of virulence genes involved in adhesion and iron acquisition, supporting the pathogenic potential of the isolate.<h4>Conclusions</h4>This report highlights the ability of MDR <i>E. coli</i> to cause severe respiratory and systemic infections in guinea pigs. The findings underline the importance of early diagnosis, appropriate antimicrobial stewardship, and improved husbandry conditions in preventing such infections. From a One Health perspective, the circulation of resistant strains in companion animals may represent a potential risk for both environmental and human health.
Source: https://pubmed.ncbi.nlm.nih.gov/42076742/
- PMID 42245977 (2026, Frontiers in veterinary science) — Uterine choriocarcinoma associated with ovarian cysts in a <i>Cavia porcellus</i>: a clinical case.. Abstract (opening): A 3. 5-year-old female guinea pig was presented for suspected hematuria. Hematology, serum biochemistry, urinalysis, and fecal examination were within normal limits; however, diagnostic imaging revealed multiple ovarian cysts and a uterine mass without evidence of metastasis. The animal underwent an ovariohysterectomy to remove the mass but died 6 h after anesthetic recovery. Histopathological examination identified a uterine adenoma with focal choriocarcinoma, associated with polycystic ovarian disease. To the authors' knowledge, this represents only the second reported case of uterine choriocarcinoma in the guinea pig. To the authors' knowledge, this is the first reported case of uterine choriocarcinoma in a guinea pig documented with a complete clinical, surgical, diagnostic imaging, histopathological, and necropsy evaluation.
Source: https://pubmed.ncbi.nlm.nih.gov/42245977/
Source text: pdf-raw/evidence/europepmc_guinea_pig_clinical_2026-08-01.txt (Europe PMC first-hand abstracts, pulled 2026-08-01).
License & attribution
Source abstracts / records are Open Access under Creative Commons. Each referenced study is reproduced with attribution under its specific CC license (CC BY / CC BY-NC / CC BY-NC-ND); the exact license variant for each reference is stated on its Europe PMC / PMC record. Original records:
- https://pubmed.ncbi.nlm.nih.gov/42076742/
- https://pubmed.ncbi.nlm.nih.gov/42245977/
- https://pubmed.ncbi.nlm.nih.gov/41902252/
- https://pubmed.ncbi.nlm.nih.gov/41642911/
Cleaning removal log (2026-08-05, codebuddy)
PMID 41728530 — rule1: human anaphylaxis case (mouse bite, sensitized to hamster); not guinea pig PMID 41631187 — rule1: human veterinarians' occupational asthma (sheep exposure); not guinea pig PMID 41541602 — rule1: human allergic rhinitis TCM review; not guinea pig PMID 42220679 — rule1: human infant congenital disorder of glycosylation; not guinea pig PMID 40743271 — rule1: human Brugada syndrome SCN5A case; not guinea pig PMID 42136742 — not-target: general review of viral RNA persistence in RG4 zoonotic viruses; no species named PMID 42072841 — rule1: human childhood coeliac disease; not guinea pig PMID 41307236 — rule2: intraocular osseous metaplasia in Norfolk Black TURKEY; different species PMID 41902252 — lab-model review (swine influenza animal models), not pet clinical (removed 2026-08-24, kimi) PMID 41642911 — in vitro lab assay (RBL-2H3 cells / hypersensitivity model), not pet clinical (removed 2026-08-24, kimi)