Evidence: Guinea pig (Cavia porcellus) toxicology
Source: Europe PMC (Europe PubMed Central) REST search — first-hand peer-reviewed abstract records, pulled 2026-08-01. Queries covered toxicology, poisoning, intoxication, heavy metals, mycotoxins and (for relevant taxa) envenomation for Cavia porcellus. The cluster returns 1 representative studies with abstracts below. Abstract text is verbatim from source; each study is traceable by PMID.
Studies
- PMID 41892407 (2026, Antibiotics (Basel, Switzerland)) — Pre-Exposure Intranasal Treatment with Neomycin Sulfate Reduces Transmission of Influenza B Virus.. Abstract (opening): <b>Background/Objectives</b>: Influenza B virus infection contributes substantially to annual morbidity and mortality, accounting for 20% to 30% of influenza-associated deaths worldwide. Although vaccination reduces the risk of severe disease, widely used inactivated influenza vaccines are often insufficient to prevent virus transmission. Moreover, influenza B viruses are less susceptible to commonly used antivirals than influenza A viruses. New approaches are therefore required to decrease disease burden and limit virus spread. Neomycin, an aminoglycoside antibiotic, was recently shown to mitigate SARS-CoV-2 transmission in a hamster model. Here, we conducted an exploratory study to assess the effect of neomycin on influenza B virus transmission. <b>Methods</b>: Contact transmission was evaluated using a guinea pig model (n = 4 per group), and aerosol transmission was assessed using a ferret model (n = 6 per group). Animals in the experimental groups received neomycin sulfate (5 mg/guinea pig, 20 mg/ferret) or placebo intranasally, starting one day before exposure to infected animals and continuing for four days thereafter. In the guinea pig study, an additional control group received intranasal interferon alpha. Viral transmission to contact animals was assessed by RT-PCR and virus culture of nasal washes collected over two weeks. Clinical signs and body weight were monitored daily. <b>Results</b>: In the guinea pig model, 75% of contact animals became infected with influenza B virus regardless of treatment. Neither neomycin nor interferon alpha prevented infection, although both delayed the onset of viral shedding in contact animals. In the ferret model, infection occurred in 33% of placebo-treated contact animals, whereas no viral shedding was detected in the neomycin-treated group. <b>Conclusions</b>: Prophylactic intranasal neomycin treatment has the potential to protect exposed individuals from aerosol transmission of influenza B virus during influenza outbreaks. *[CC BY — Open Access, verbatim with attribution.]*
Source: https://pubmed.ncbi.nlm.nih.gov/41892407/
Source text: pdf-raw/evidence/europepmc_guinea_pig_toxicology_2026-08-01.txt (Europe PMC first-hand abstracts, pulled 2026-08-01).
License & attribution
Mixed licensing per COPYRIGHT_POLICY §3: Open Access (CC BY / CC BY-NC / CC BY-NC-ND) studies are reproduced verbatim with attribution under their specific CC license; non-Open-Access studies are paraphrased as derived fact summaries (numbers and proper nouns preserved, sentences rewritten). Original records:
- https://pubmed.ncbi.nlm.nih.gov/41842687/
- https://pubmed.ncbi.nlm.nih.gov/42021609/
- https://pubmed.ncbi.nlm.nih.gov/42076742/
- https://pubmed.ncbi.nlm.nih.gov/42135602/
- https://pubmed.ncbi.nlm.nih.gov/41948330/
- https://pubmed.ncbi.nlm.nih.gov/41892407/
- https://pubmed.ncbi.nlm.nih.gov/41894455/
Cleaning removal log (2026-08-05, codebuddy)
PMID 41940042 — rule3: guinea pig ototoxicity/otoprotection models for human hearing; model organism, not pet subject PMID 42056012 — not-target: neurotrophins in cochlear implantation review (human patients); no guinea pig named PMID 42292475 — rule3: BDNF form-deprivation myopia model in guinea pigs (human myopia); model organism, not pet subject PMID 42312175 — rule3: Mycobacterium tuberculosis infection model in guinea pigs (host-directed TB therapy); model organism, not pet subject PMID 41842687 — human food-safety QMRA (Listeria stillbirth dose-response), not pet toxicology (removed 2026-08-24, kimi) PMID 42021609 — bench pharmacology (guinea-pig aortic rings, 5-HT2B), not pet toxicology (removed 2026-08-24, kimi) PMID 42076742 — mis-clustered duplicate — kept in evidence_exotic_guinea_pig_clinical (removed 2026-08-24, kimi) PMID 42135602 — developmental-toxicology reference (placental FcRn, human/animal), not pet toxicology (removed 2026-08-24, kimi) PMID 41948330 — animal-model development review, not pet toxicology (removed 2026-08-24, kimi) PMID 41894455 — in vitro dermal model (hairless guinea pig), not pet toxicology (removed 2026-08-24, kimi)