Penicillin toxicity syndromes in guinea pigs — toxic, hemorrhagic, chronic (Green 1974, PMID 4446629)
The text below is reproduced verbatim from the first-hand source.
Claims (verified C1 substrings of source_file)
- `The association of viral activation with penicillin toxicity in guinea pigs and
hamsters.`
- `This finding has been construed as being activation
of a latent virus by this antibiotic, but the relationship, if any, of the phenomenon of viral activation to the syndromes produced by penicillin and its frequent lethal toxicity is unknown.`
- `Of some 60 guinea pigs which received injections of
penicillin three developed tumors and four others were found to have gallstones.`
- `A virus similar or identical to the guinea pig virus also has been isolated from
hamsters dying of penicillin-induced disease.`
- `It is hypothesized that the
absorption of endotoxin, resulting from the well known change in intestinal flora caused by penicillin, produces a state of immunodeficiency which regularly gives rise to activation of a latent virus, and perhaps, rarely, to the development of malignant neoplasms.`
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Source: pdf-raw/exotic-toxicology/pubmed_4446629_penicillin_guineapig_hamster.txt · https://pmc.ncbi.nlm.nih.gov/articles/PMC2595098/